Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum
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چکیده
منابع مشابه
Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum
BACKGROUND Fatty acid synthase (FAS) is a promising antifungal target due to its marked structural differences between fungal and mammalian cells. The aim of this study was to evaluate the antifungal activity of flavonoids described in the scientific literature as FAS inhibitors (quercetin, trans-chalcone, ellagic acid, luteolin, galangin, and genistein) against the dermatophyte Trichophyton ru...
متن کاملGene expression profiling in the human pathogenic dermatophyte Trichophyton rubrum during growth on proteins.
Dermatophytes are highly specialized filamentous fungi which cause the majority of superficial mycoses in humans and animals. The high secreted proteolytic activity of these microorganisms during growth on proteins is assumed to be linked to their particular ability to exclusively infect keratinized host structures such as the skin stratum corneum, hair, and nails. Individual secreted dermatoph...
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Background Dermatophytosis are fungal infections caused by keratinophilic fungi known as dermatophytes and classified in three genera: Trichophyton, Epidermophyton and Microsporum. Trichophyton rubrum is the most frequent species associated to dermatophytosis worldwide [1]. The infections caused by dermatophytes are not lethal, but are difficult to treat and uncomfortable. In the case of T. rub...
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Although Trichophyton rubrum is the dermatophyte morecommonly found in lesions of human skin and nails [1], itsgenetic and biological aspects are still poorly understood. Inorder to better understand gene expression in thispathogen, we used the SAGE (Serial Analysis of GeneExpression) technique to characterize the transcriptomeprofile of this fungus. Originally developed...
متن کاملElectrophoretic molecular karyotype of the dermatophyte Trichophyton rubrum
The electrophoretic karyotype of the dermatophyte Trichophyton rubrum was established using contour-clamped homogeneous electric field (CHEF) gel electrophoresis. Five chromosomal bands of approximately 3.0 to 5.8 megabase pairs (Mbp) each were observed and together indicated that 22.05 Mbp of the total genome are organized as chromosomal macromolecules. In addition to establishing the number a...
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ژورنال
عنوان ژورنال: BMC Complementary and Alternative Medicine
سال: 2013
ISSN: 1472-6882
DOI: 10.1186/1472-6882-13-229